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  3. Dirk Lange

Dirk Lange

Associate Professor
Academic Appointment
Associate Professor
Research Focus
Kidneys and Urinary System
Degrees / Designations

B.Sc. (Hon), PhD

Contact Info
dirk.lange@ubc.ca
604-875-4111
DLangePhD
dirk-lange-b7026b14/

Biography

Dr. Dirk Lange is a microbiologist who earned his PhD in microbiology and immunology from the University of Western Ontario. Since joining the Department of Urologic Sciences at the University of British Columbia in 2008 as a postdoctoral fellow and transitioning into a faculty position in 2011, he has been instrumental in developing an internationally renowned translational research program at the Stone Centre at Vancouver General Hospital focused on the treatment of kidney stone disease. This unique research program is one of only a handful worldwide dedicated to kidney stone disease that places basic scientists and clinicians side-by-side, allowing for truly translational research. 

One of Dr. Lange’s major contributions to the field has been in the area of ureteral stent biomaterial design, where he has done extensive work on understanding mechanisms that drive ureteral stent-associated complications including bacterial biofilm formation, device encrustation, pain and discomfort. Furthermore, he is actively involved in the development of novel anti-fouling coatings for medical devices including ureteral stents and urinary catheters, as well as the development of a biodegradable ureteral stent. Furthermore, given his background in microbiology and immunology, Dr. Lange’s research program also involves studying the role of the intestinal microbiome and urinary microbiome in urologic disease including kidney stone disease, bladder cancer and kidney transplant rejection.

In recognition of his contributions, Dr. Lange was named a VCHRI Rising Star, Urology Care Foundation Research Scholar and a CIHR New Investigator.

News and Awards

‘Silver bullet’ coating technologies to keep medical devices free of bacteria

Apr 27, 2022

Innovation and Translational Research Awards 2020 Recipients

Jun 23, 2020

Same lifestyle, different stones: The link between diet, gut bacteria and kidney stones

May 23, 2018

Ask an expert: How do I keep my hard-working kidneys healthy?

Mar 4, 2018

Comparing partners’ gut bacteria may be key to preventing kidney stones

Aug 12, 2015

Publications

  • Kidney international -

    Inhibition of urinary stone disease by a multi-species bacterial network ensures healthy oxalate homeostasis.

    Miller AW, Choy D, Penniston KL, Lange D
  • ACS central science -

    Durable Surfaces from Film-Forming Silver Assemblies for Long-Term Zero Bacterial Adhesion without Toxicity.

    Yazdani-Ahmadabadi H, Felix DF, Yu K, Yeh HH, Luo HD, Khoddami S, Takeuchi LE, Alzahrani A, Abbina S, Mei Y, Fazli L, Grecov D, Lange D, Kizhakkedathu JN
  • Advanced healthcare materials -

    Self-Limiting Mussel Inspired Thin Antifouling Coating with Broad-Spectrum Resistance to Biofilm Formation to Prevent Catheter-Associated Infection in Mouse and Porcine Models.

    Yu K, Alzahrani A, Khoddami S, Ferreira D, Scotland KB, Cheng JTJ, Yazdani-Ahmadabadi H, Mei Y, Gill A, Takeuchi LE, Yeung E, Grecov D, Hancock REW, Chew BH, Lange D, Kizhakkedathu JN
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences -

    Determination of urinary prostaglandin E₂ as a potential biomarker of ureteral stent associated inflammation.

    Huang ZA, Scotland KB, Li Y, Tan J, Kung SHY, Chew BH, Chen DDY, Lange D
  • Urology -

    A Role for the Hedgehog Effector Gli1 in Mediating Stent-induced Ureteral Smooth Muscle Dysfunction and Aperistalsis.

    Janssen C, Buttyan R, Seow CY, Jäger W, Solomon D, Fazli L, Chew BH, Lange D
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