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  2. Our Research
  3. Xuesen Dong

Xuesen Dong

Associate Professor
Academic Appointment
Associate Professor
Research Focus
Kidneys and Urinary SystemProstate Diseases
Degrees / Designations

PhD

Contact Info
xdong@prostatecentre.com
604-875-4111 ext.63020

Biography

Dr. Xuesen Dong is a senior scientist at the Vancouver Prostate Centre and an associate professor in the Department of Urologic Sciences at the University of British Columbia (UBC). He received medical school training in China before coming to Canada. He completed a Master of Science in molecular and cellular biology from Laval University and a PhD in physiology from the University of Toronto. He received post-doctoral training from the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto and the Vancouver Prostate Centre. Dr. Dong was a recipient of several scholarships for his doctoral and postdoctoral training, received a Rising Star Award from Prostate Cancer Canada, and has been continuously funded by Canadian Institutes of Health Research grants since 2005.

Dr. Dong’s laboratory investigates the molecular mechanism by which prostate tumors develop therapy resistance with emphasis on RNA binding proteins that promote treatment-resistant disease progression. His lab applies computer-aided drug design to develop new anti-cancer drugs and RNA sequencing technology to explore cell-free circular RNA as diagnostic markers. 

News and Awards

People in profile: Ahn Lee

Aug 15, 2017

Top Graduating Doctoral Student Award and Rising Star Award 2017 Recipients

May 28, 2017

Publications

  • Nature cell biology -

    A PRC2-independent function for EZH2 in regulating rRNA 2'-O methylation and IRES-dependent translation.

    Yi Y, Li Y, Meng Q, Li Q, Li F, Lu B, Shen J, Fazli L, Zhao D, Li C, Jiang W, Wang R, Liu Q, Szczepanski A, Li Q, Qin W, Weiner AB, Lotan TL, Ji Z, Kalantry S, Wang L, Schaeffer EM, Niu H, Dong X, Zhao W, Chen K, Cao Q
  • Proceedings of the National Academy of Sciences of the United States of America -

    A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer.

    Xu L, Yin Y, Li Y, Chen X, Chang Y, Zhang H, Liu J, Beasley J, McCaw P, Zhang H, Young S, Groth J, Wang Q, Locasale JW, Gao X, Tang DG, Dong X, He Y, George D, Hu H, Huang J
  • Cancer research -

    KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer.

    Gao L, Zhang W, Zhang J, Liu J, Sun F, Liu H, Hu J, Wang X, Wang X, Su P, Chen S, Qu S, Shi B, Xiong X, Chen W, Dong X, Han B
  • Frontiers in oncology -

    Discovery of New Catalytic Topoisomerase II Inhibitors for Anticancer Therapeutics.

    Matias-Barrios VM, Radaeva M, Song Y, Alperstein Z, Lee AR, Schmitt V, Lee J, Ban F, Xie N, Qi J, Lallous N, Gleave ME, Cherkasov A, Dong X
  • Frontiers in cell and developmental biology -

    Perspectives on Circular RNAs as Prostate Cancer Biomarkers.

    Fang J, Qi J, Dong X, Luo J
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