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  3. Horacio Bach

Horacio Bach

Clinical Assistant Professor
VCH Clinical Title(s)
Manager, Immunity and Infection Research Centre's Proteomic and Antibody Engineering Facility
Research Focus
Immune System
Degrees / Designations

PhD

Contact Info
hbach@mail.ubc.ca

Biography

Dr. Horacio Bach is a researcher at the Immunity and Infection Research Centre and a clinical assistant professor in the Faculty of Medicine, Division of Infectious Diseases at the University of British Columbia. His current research interests include mechanism elucidation of virulence factors of members of the pathogenic Mycobacterium group and understanding how intracellular microorganisms subvert the host and successfully establish infections. He also is interested in understanding the role of Mycobacterium paratuberculosis in inflammatory bowel diseases, which is suspected to be involved in Crohn's disease in humans. Through clinical collaborations, he has found the presence of anti-Mycobacterium paratuberculosis antibodies in patients with Crohn's disease, rheumatoid arthritis and multiple sclerosis.

Dr. Bach’s laboratory is engaged in multiple projects to design single-chain antibodies using a proprietary library from human cells. His team is engaged in developing single-chain antibodies to neutralize SARS-CoV-2, the causative of COVID-19. These neutralizing antibodies are applied intranasally, targeting the viruses before infection. In addition, they are developing new antimicrobial agents based on nanoparticles to treat multidrug-resistant pathogens, including intracellular bacteria.

Read more about Dr. Bach's recent research here.

News and Awards

A nano silver bullet for treatment-resistant bacteria

Feb 20, 2022

Ask an expert: Which masks provide the best protection against COVID-19?

Jan 30, 2022

An inhaled drug cocktail could block COVID-19

Sep 17, 2020

Researchers trying to 'bring smiles back' to kids with rare cancer

Feb 21, 2016

Publications

  • Nanomaterials (Basel, Switzerland) -

    Targeting Intracellular Mycobacteria Using Nanosized Niosomes Loaded with Antibacterial Agents.

    Slavin YN, Ivanova K, Tang WL, Tzanov T, Li SD, Bach H
  • ACS applied materials & interfaces -

    Novel Lignin-Capped Silver Nanoparticles against Multidrug-Resistant Bacteria.

    Slavin YN, Ivanova K, Hoyo J, Perelshtein I, Owen G, Haegert A, Lin YY, LeBihan S, Gedanken A, Häfeli UO, Tzanov T, Bach H
  • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases -

    Treatment of COVID-19 with convalescent plasma: lessons from past coronavirus outbreaks.

    Wooding DJ, Bach H
  • Microorganisms -

    Subspecies Infects and Replicates within Human Monocyte-Derived Dendritic Cells.

    Rees WD, Lorenzo-Leal AC, Steiner TS, Bach H
  • Microorganisms -

    Development of Coronavirus Treatments Using Neutralizing Antibodies.

    Fouladirad S, Bach H
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