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  2. Our Research
  3. Mads Daugaard

Mads Daugaard

Associate Professor
VCH Clinical Title(s)
Molecular Biologist
Research Focus
Cancers
Degrees / Designations

B.Sc., M.Sc., PhD

Contact Info
mads.daugaard@ubc.ca
604-875-4111 x21792
madsdaug1
madsdaugaard

Biography

Dr. Mads Daugaard is a molecular biologist specialized in tumour-associated stress signaling pathways and tumour targeting systems. He earned his PhD from the Faculty of Health Sciences at the University of Copenhagen for his studies on heat shock proteins in relation to cancer cell survival mechanisms. After completing his PhD, he received a junior fellowship award to continue his work at the Danish Cancer Society Research Centre on stress signaling pathways related to DNA damage response mechanisms. In 2010, he received a research award from the Danish Cancer Society Scientific Committee to do postdoctoral training in molecular pathology at the BC Cancer Research Centre and the Department of Pathology and Laboratory Medicine at the University of British Columbia.

Dr. Daugaard was recruited to the Vancouver Prostate Centre in 2014 as a senior research scientist and group leader. His ongoing research focuses on molecular and biochemical events underlying alternative polyadenylation of mRNAs, chromatin context-dependent DNA repair, development of resistance to chemotherapy, and immune-evasion mechanisms in cancer. Another aspect of Dr. Daugaard’s research relates to discovery and development of novel tumour targeting systems based on parasite-derived recombinant proteins relevant for therapeutic and diagnostic applications in cancer.

Dr. Daugaard has published original research in top-tier scientific journals and received competitive international funding support from institutions such as the US Department of Defense, Canadian Institutes of Health Research, National Institutes of Health, Stand Up 2 Cancer, and Vancouver Coastal Health Research Institute. In the 2014 competition, Dr. Daugaard received the Prostate Cancer Canada and Safeway Rising Star Award. Dr. Daugaard has served as an editor of Cell Death & Disease (Nature Publishing Group) since 2016. In 2012, Dr. Daugaard co-founded the biotechnology companies VAR2 Pharmaceuticals and OncoMal, and in 2017, the diagnostic company VarCT Diagnostics. In 2021 Dr. Daugaard co-founded the small-molecule cancer therapeutic company Rakovina Therapeutics.

News and Awards

New molecule could enhance the efficacy of childhood cancer treatments

Jan 8, 2020

Innovation and Translational Research Awards 2019 Recipients

Aug 13, 2019

Award supports research into broad-spectrum childhood cancer treatments

May 21, 2019

People in profile: Maj Sofie Ørum-Madsen

Mar 21, 2019

Malaria leads a new charge against bladder cancer

Apr 20, 2017

Drug created from malaria parasite shows promise as bladder cancer treatment

Apr 20, 2017

Social media helps expand groundbreaking findings on malaria as potential cancer treatment

Oct 23, 2015

Destructive disease shows potential as a cancer treatment

Oct 8, 2015

Publications

  • Cancer discovery -

    Proteomic screens for suppressors of anoikis identify IL1RAP as a promising surface target in Ewing sarcoma.

    Zhang HF, Hughes CS, Li W, He JZ, Surdez D, El-Naggar AM, Cheng H, Prudova A, Delaidelli A, Negri GL, Li X, Orum-Madsen MS, Lizardo MM, Oo HZ, Colborne S, Shyp T, Scopim-Ribeiro R, Hammond CA, Dhez AC, Langman S, Lim JK, Kung SH, Li A, Steino A, Daugaard M, Parker SJ, Klein Geltink RI, Orentas RJ, Xu LY, Morin GB, Delattre O, Dimitrov DS, Sorensen PH
  • Cells -

    A Potential Role for HUWE1 in Modulating Cisplatin Sensitivity.

    Wenmaekers S, Viergever BJ, Kumar G, Kranenburg O, Black PC, Daugaard M, Meijer RP
  • Cell death & disease -

    Development of a bispecific immune engager using a recombinant malaria protein.

    Nordmaj MA, Roberts ME, Sachse ES, Dagil R, Andersen AP, Skeltved N, Grunddal KV, Erdoğan SM, Choudhary S, Gustsavsson T, Ørum-Madsen MS, Moskalev I, Tian W, Yang Z, Clausen TM, Theander TG, Daugaard M, Nielsen MA, Salanti A
  • Oncogene -

    HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner.

    Turgu B, Zhang F, El-Naggar A, Negri GL, Kogler M, Tortola L, Johnson F, Ng T, Li A, Yapp D, Lockwood W, Martinez D, Maris JM, Daugaard M, Penninger JM, Hughes CS, Sorensen PH
  • Glycobiology -

    An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

    Toledo AG, Pihl J, Spliid CB, Persson A, Nilsson J, Pereira MA, Gustavsson T, Choudhary S, Oo HZ, Black PC, Daugaard M, Esko JD, Larson G, Salanti A, Clausen TM
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