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  3. Ear, Nose and Throat

Ear, Nose and Throat

Recruiting

Testing metformin to prevent oral cancer in people with oral leukoplakia or erythroplakia

The purpose of this study is to determine if metformin can stop changes in the mouth that are related to pre-cancer growths such as oral leukoplakia (white patches) or erythroplakia (red patches) or cancer of the mouth. The study will compare the safety and effects of metformin with the safety and effects of placebo on people’s risk of developing cancer of the mouth.

Status
Recruiting
Body Locations and Systems
Ear, Nose and Throat
Age
21 and above

Improving Hearing Assessment in Newborns

To determine how much noise is required during testing to make sure that each ear is assessed separately during an auditory assessment in infants. 

Status
Recruiting
Principal Investigator
Susan Small
Body Locations and Systems
Hearing Disorders and Deafness
Area
Vancouver
Age
18 months old or younger

Thalamic Deep Brain Stimulation for Spasmodic Dysphonia- DEBUSSY Trial

Laryngeal Dystonia (LD), also commonly referred to as spasmodic dysphonia, is a neurological voice disorder characterized by involuntary dystonic contractions of the laryngeal muscles. Current treatments such as botox and voice therapy only provide temporary relief and thus, the investigators are exploring new strategies to provide long-term, sustained improvement.

Status
Recruiting
Principal Investigator
Christopher Honey
Body Locations and Systems
Brain
Throat
Area
Vancouver
Age
18-75

Closed for Recruitment

Controlled Clinical Study of Dupilumab in Patients With Nasal Polyps

Primary Objective:

To evaluate the efficacy of dupilumab compared to placebo on a background of mometasone furoate nasal spray (MFNS) in reducing nasal congestion/obstruction (NC) severity and endoscopic nasal polyposis score (NPS) in patients with bilateral nasal polyposis (NP). In addition for Japan, reduction in computed tomography (CT) scan opacification of the sinuses will be also a co-primary objective.

Secondary Objectives:

To evaluate the efficacy of dupilumab in improving total symptoms score (TSS).

Status
Closed for Recruitment
Body Locations and Systems
Nose
Lungs and Breathing
Area
Vancouver
Age
18 and above
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