The purpose of this study is to determine if metformin can stop changes in the mouth that are related to pre-cancer growths such as oral leukoplakia (white patches) or erythroplakia (red patches) or cancer of the mouth. The study will compare the safety and effects of metformin with the safety and effects of placebo on people’s risk of developing cancer of the mouth.
To determine how much noise is required during testing to make sure that each ear is assessed separately during an auditory assessment in infants.
Laryngeal Dystonia (LD), also commonly referred to as spasmodic dysphonia, is a neurological voice disorder characterized by involuntary dystonic contractions of the laryngeal muscles. Current treatments such as botox and voice therapy only provide temporary relief and thus, the investigators are exploring new strategies to provide long-term, sustained improvement.
Closed for Recruitment
To evaluate the efficacy of dupilumab compared to placebo on a background of mometasone furoate nasal spray (MFNS) in reducing nasal congestion/obstruction (NC) severity and endoscopic nasal polyposis score (NPS) in patients with bilateral nasal polyposis (NP). In addition for Japan, reduction in computed tomography (CT) scan opacification of the sinuses will be also a co-primary objective.
To evaluate the efficacy of dupilumab in improving total symptoms score (TSS).