Improving Hearing Assessment in Newborns
To determine how much noise is required during testing to make sure that each ear is assessed separately during an auditory assessment in infants.
Status
Recruiting
Recruiting
Thalamic Deep Brain Stimulation for Spasmodic Dysphonia- DEBUSSY Trial
Laryngeal Dystonia (LD), also commonly referred to as spasmodic dysphonia, is a neurological voice disorder characterized by involuntary dystonic contractions of the laryngeal muscles. Current treatments such as botox and voice therapy only provide temporary relief and thus, the investigators are exploring new strategies to provide long-term, sustained improvement.
Status
Recruiting
Closed for Recruitment
Understanding saliva and swallowing in Sjogren’s disease and healthy adults
This study will evaluate how changes in saliva composition can affect swallowing in Sjogren’s disease and healthy individuals. Sjogren’s disease leads to changes in saliva, including the amount produced and the components in saliva (e.g. proteins). These changes can contribute to dry mouth and problems with swallowing. This research will provide information for clinicians working with swallowing disorders, to promote earlier diagnosis and treatment.
Status
Closed for Recruitment
Testing metformin to prevent oral cancer in people with oral leukoplakia or erythroplakia
The purpose of this study is to determine if metformin can stop changes in the mouth that are related to pre-cancer growths such as oral leukoplakia (white patches) or erythroplakia (red patches) or cancer of the mouth. The study will compare the safety and effects of metformin with the safety and effects of placebo on people’s risk of developing cancer of the mouth.
Status
Closed for Recruitment
Controlled Clinical Study of Dupilumab in Patients With Nasal Polyps
Primary Objective:
To evaluate the efficacy of dupilumab compared to placebo on a background of mometasone furoate nasal spray (MFNS) in reducing nasal congestion/obstruction (NC) severity and endoscopic nasal polyposis score (NPS) in patients with bilateral nasal polyposis (NP). In addition for Japan, reduction in computed tomography (CT) scan opacification of the sinuses will be also a co-primary objective.
Secondary Objectives:
To evaluate the efficacy of dupilumab in improving total symptoms score (TSS).
Status
Closed for Recruitment