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Lungs

Recruiting

Assessing rocatinlimab in moderate-to-severe asthma

The purpose of this study is to investigate whether rocatinlimab is safe and effective in reducing asthma symptoms (such as an asthma exacerbation, also known as an asthma attack) and improving lung function, as well as whether it causes any side effects.

Status
Recruiting
Principal Investigator
Céline Bergeron
Body Locations and Systems
Lungs and Breathing
Asthma
Age
19-75

Assessing the effect of dexpramipexole in people with severe eosinophilic asthma

The purpose of this study is to investigate the safety, tolerability and efficacy of dexpramipexole in participants with inadequately controlled severe eosinophilic asthma.

Status
Recruiting
Principal Investigator
Céline Bergeron
Body Locations and Systems
Lungs and Breathing
Asthma
Age
19 and above

IMPACT

The purpose of this study is to build a tool to support medical decision-making and the integration of a validated clinical-prediction model into routine care for individuals with chronic obstructive pulmonary disease (COPD).

Status
Recruiting
Principal Investigator
Mohsen Sadatsafavi
Body Locations and Systems
Lungs and Breathing
COPD

Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma

The purpose of this study is to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care.

Status
Recruiting
Principal Investigator
Céline Bergeron
Body Locations and Systems
Lungs and Breathing
Asthma
Area
Vancouver
Age
12-80

Lung health benefits of e-cigarette cessation

The purpose of this study is to determine the lung and immune function benefits of stopping vaping for 72 hours in young adults who use e-cigarettes containing nicotine. The study also aims to determine if telling participants of their own personalized changes to their lung and immune function following the 72 hour abstinence period affects their motivation in quitting vaping.

Status
Recruiting
Principal Investigator
Christopher Carlsten
Body Locations and Systems
Smoking Cessation
Area
Vancouver
Age
19 - 35

International Lung Screen Trial (ILST)

People who may be at increased risk of lung cancer due to age and smoking history will be invited to participate in this international study to determine the best way of using computed tomography (CT) of the chest to screen for early lung cancer. Overseas data show that CT screening (screening tests can find diseases early, when they're easier to treat) can reduce deaths from lung cancer and this study will help determine who is most likely benefit from screening.

Status
Recruiting
Principal Investigator
Stephen Lam
Body Locations and Systems
Lung Cancer
Area
Vancouver
Age
55-80

Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure (ADVENT-HF)

Sleep Apnea (SA) is a disorder that causes pauses in breathing during sleep that expose the heart to oxygen deprivation. It is common in patients with heart failure (HF) where it is associated with increased risk of hospitalizations and death. It is not known however whether treating SA reduces these risks. This study is looking at whether a respiratory device known as Adaptive Servo Ventilation (ASV) can reduce the rate of cardiovascular hospitalizations and death in subjects with HF and SA.

Status
Recruiting
Principal Investigator
John Fleetham
Body Locations and Systems
Heart Failure
Sleep Apnea Syndromes
Area
Vancouver
Age
18 and above

Closed for Recruitment

Assessing the effect of dexpramipexole in people with eosinophilic asthma

The purpose of this study is to evaluate dexpramipexole as an add-on therapy in participants with inadequately controlled eosinophilic asthma, on Global Initiative for Asthma (GINA) 2021 Step 3, 4 or 5 therapy (or GINA 2021 Step 4 or 5 therapy in Poland) to confirm improvements in lung function, asthma control and quality of life.

Status
Closed for Recruitment
Principal Investigator
Céline Bergeron
Body Locations and Systems
Lungs and Breathing
Asthma
Age
19 and above

Assessing the efficacy of rilzabrutinib in adults with moderate-to-severe asthma

The purpose of this study is to evaluate the safety, tolerability and effectiveness of rilzabrutinib (also known as SAR444671) compared to a placebo in adults with moderate-to-severe asthma.

Status
Closed for Recruitment
Principal Investigator
Céline Bergeron
Body Locations and Systems
Lungs and Breathing
Asthma
Age
18-70

Canadian Asthma Text Messaging Study

The purpose of this study is to understand asthmatic patients' knowledge, perceptions and viewpoints about using a telehealth approach to manage their asthma conditions.

Status
Closed for Recruitment
Body Locations and Systems
Lungs and Breathing
Asthma
Age
21 and above

APIxaban Cancer Associated Thrombosis (API-CAT)

The purpose of this study is to determine whether a reduced dose of apixaban is non-inferior to and safer than the full dose of apixaban for the prevention of recurrent venous thromboembolism (VTE) in active cancer patients.

Status
Closed for Recruitment
Principal Investigator
Agnes Lee
Body Locations and Systems
Blood, Heart and Circulation
Blood Clots
Deep Vein Thrombosis
Pulmonary Embolism
Area
Vancouver
Age
18 and above

A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary Hypertension (REBUILD)

The purpose of this study is to assess the safety and efficacy of pulsed inhaled nitric oxide versus placebo in subjects at risk for pulmonary hypertension associated with pulmonary fibrosis on long term oxygen therapy.

Status
Closed for Recruitment
Principal Investigator
Nasreen Khalil
Body Locations and Systems
Pulmonary Fibrosis
Pulmonary Hypertension
Area
Vancouver
Age
18 - 80

Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension

The purpose of this study is determine if a fixed-dose combination of the drugs macitentan and tadalafil is more effective than therapy with macitentan or tadalafil alone to treat pulmonary arterial hypertension.

Status
Closed for Recruitment
Principal Investigator
John Swiston
Body Locations and Systems
Pulmonary Hypertension
Area
Vancouver
Age
18 - 75

Study of Efficacy and Safety of CSJ117 in Patients With Severe Uncontrolled Asthma

The purpose of this study is to test the safety and efficacy of an inhaled medication (CSJ117) compared with a placebo for improving lung function in patients with inadequate control of moderate to severe asthma.

Status
Closed for Recruitment
Principal Investigator
Céline Bergeron
Body Locations and Systems
Asthma
Area
Vancouver
Age
18 - 75

A Study to Evaluate the Efficacy and Safety of Dupilumab in Participants With Allergic Bronchopulmonary Aspergillosis

The purpose of this study is to determine if dupilumab is effective and safe in decreasing episodes of severe breathing difficulties in patients with allergic bronchopulmonary aspergillosis (ABPA).

Status
Closed for Recruitment
Body Locations and Systems
Lungs
Area
Vancouver
Age
18 and above

Public engagement of wildfire smoke exposure and public health messages in BC

The purpose of this study is to determine if BC residents receive, understand and implement public health messages related to wildfire smoke exposures, and to better understand the reach of these messages and identify opportunities for future improvement.

Status
Closed for Recruitment
Principal Investigator
Christopher Carlsten
Body Locations and Systems
Lungs
Area
Vancouver
Age
18 and above

A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery and/or International Treatment (SELECT)

The purpose of this study aims to assess the efficacy and safety of selexipag in patients with inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH).

Status
Closed for Recruitment
Principal Investigator
Nathan Brunner
Body Locations and Systems
Blood, Heart and Circulation
Heart
Lungs
Area
Vancouver
Age
18-85

Care during COVID-19 survey

The purpose of this study is to understand how patients with asthma and COPD have been affected by the changes to the health care system as a result of the COVID-19 pandemic.

Status
Closed for Recruitment
Principal Investigator
Christopher Carlsten
Body Locations and Systems
Asthma
COPD
Area
Vancouver
Age
18 and above

Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER (RANGER)

This extended access study will assess the long-term safety and tolerability of bardoxolone methyl in qualified patients with pulmonary hypertension (PH) who previously participated in controlled clinical studies with bardoxolone methyl.

Status
Closed for Recruitment
Principal Investigator
John Swiston
Body Locations and Systems
Pulmonary Hypertension
Area
Vancouver
Age
18-85 years

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy (REPLACE)

To demonstrate the effectiveness of riociguat as replacement of phosphodiesterase-5 inhibitors (PDE-5i) therapy in pulmonary arterial hypertension (PAH) patients

Status
Closed for Recruitment
Principal Investigator
John Swiston
Body Locations and Systems
Pulmonary Hypertension
Area
Vancouver
Age
18-75 years

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