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  3. Diagnostic Imaging

Diagnostic Imaging

Recruiting

Improving our understanding of functioning in psychosis

The purpose of this study is to contribute to improving our understanding of functioning in psychosis. Memory is an important predictor of how well individuals affected by schizophrenia and related psychoses are able function in their social and occupational lives. However, the exact structures and functions in the brain responsible for this relationship are currently unknown.

Status
Recruiting
Principal Investigator
Todd Woodward
Body Locations and Systems
Brain and Nerves
Age
18-60

Predicting treatment outcomes for major depression

The purpose of this study is to test whether a specific combination of biomarkers discovered during previous studies can help predict how someone experiencing a major depressive episode will respond to treatment. The study will also explore other possible biomarkers that may predict treatment response, which may help in the future development of tests that can guide treatment choice more effectively and more quickly.

Status
Recruiting
Principal Investigator
Raymond Lam
Body Locations and Systems
Brain and Nerves
Age
18-60

Automated detection of autonomic dysreflexia via deep learning

The purpose of this study is to investigate if and how retinal blood vessels change after a spinal cord injury (SCI) and the associations of these changes with cardiovascular diseases. Using images of retinal blood vessels, we will develop a deep learning-based screening tool for autonomic dysreflexia, a cardiovascular complication unique to SCI.

Recruitment Poster

Status
Recruiting
Principal Investigator
Ipek Oruc
Body Locations and Systems
Blood, Heart and Circulation
Eyes and Vision

fMRI and Response Inhibition in Individuals with Bipolar Disorder

The purpose of this study is to look at the link between regions of brain activity and impulsivity and to look at a non-invasive intervention called repetitive transcranial magnetic stimulation (rTMS) to help reduce the risk of impulsive behaviours.

Status
Recruiting
Principal Investigator
Christian Schütz
Body Locations and Systems
Brain and Nerves
Area
Vancouver
Age
19-45

CAN-ACCESS

The purpose of the study is to find the best technique and tools for gaining access to left and right heart arteries using x-rays that show blood flow, in patients who are having a specific Medtronic heart valve inserted.

Status
Recruiting
Principal Investigator
Janarthanan Sathananthan
Body Locations and Systems
Heart
Area
Vancouver
Age
18 and above

Effects of Sex on Belt Fit in Relation to Skeletal Geometry

The purpose of this study is to determine if there are sex differences in seatbelt fit by quantifying male and female volunteers’ seatbelt fits relative to external body geometry and skeletal posture using an upright MRI. 

Status
Recruiting
Principal Investigator
Peter Cripton
Area
Vancouver
Age
19-60

Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE)

The purpose of the study is to compare differences in blood flow and valve pressures by two different methods in patients who are having transcatheter aortic valve replacement.

Status
Recruiting
Principal Investigator
David Wood
Body Locations and Systems
Heart Disease
Area
Vancouver

Using imaging to aid heart attack diagnosis

The purpose of this study is to employ standardized imaging protocols in women and men with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each participant. Participants will be followed for recurrent clinical events, every six months, for a maximum of 10 years.

Status
Recruiting
Principal Investigator
Tara Sedlak
Body Locations and Systems
Blood, Heart and Circulation
Area
Vancouver
Age
21-99

Correlation Between PET and Advanced MRI in Multiple Sclerosis

This is an observational study designed to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health. 

Status
Recruiting
Principal Investigator
Robert Carruthers
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18-60

Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND)

The CCNA COMPASS-ND study aims to investigate the bases, commonalities, and distinguishing characteristics of Alzheimer disease and related neurodegenerative disorders. 

Recruitment Poster

Status
Recruiting
Principal Investigator
Ging-Yuek Robin Hsiung
Body Locations and Systems
Alzheimer's Disease
Dementia
Area
Vancouver
Age
50-85

Serial Comparisons of Abdominal and Neurological MRI Scans (SCANMRI)

The purpose of this study is to compare abdominal weight gain and fat distribution to changes in brain morphology in people taking antipsychotic medications.

Status
Recruiting
Body Locations and Systems
Brain
Area
Vancouver
Age
12 and above

Repetitive Transcranial Magnetic Stimulation in the Treatment of Major Depressive Disorder

This trial will compare a novel form of rTMS, intermittent Theta Burst Stimulation to the standard conventional high frequency left sided stimulation protocol. The Left dorsolateral prefrontal cortex will be the site of stimulation in both treatment conditions. The site of stimulation will be targeted using MRI co-registration.

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Depression
Area
Vancouver
Age
51-60

Closed for Recruitment

Somatotopy in Parkinson’s disease

The purpose of this study is to investigate changes in the brain in people affected by Parkinson’s disease using PET and fMRI imaging.

Status
Closed for Recruitment
Principal Investigator
Jon Stoessl
Body Locations and Systems
Brain and Nerves
Area
Vancouver
Age
50-85

Establishing an Imaging Biomarker for Disease Progression in Multiple Sclerosis

MS is a disabling neurological disease with a highly variable clinical course including acute disability (relapses when symptoms appear or worsen) and disease progression (steady accumulation of disability in the absence of relapses). There is currently no approved treatment for progressive MS. A principal pathology of MS is the destruction of myelin, which surrounds nerves to speed up signal conduction. We have developed a magnetic resonance imaging technique that provides quantitative measurements of myelin.

Status
Closed for Recruitment
Principal Investigator
Shannon Kolind
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18-65

Imaging Tau Accumulation with PBB3 in Healthy Controls

Parkinson's disease results from the loss of dopamine producing brain cells; however, the mechanism that start and continue this loss are still largerly unknkown. Recent research has suggested a protein called tau may contribute to the development and progression of Parksinon's disease. Using Positron Emission Tomography (PET), a brain imaging technique, we hope to determine if and how much tau is present in healthy control subjects. This control data will then be used for comparison for data collected in patients with Parkinson's and related diseases.

Status
Closed for Recruitment
Principal Investigator
Jon Stoessl
Body Locations and Systems
Parkinson's Disease
Area
Vancouver
Age
19-85

Characterization of Dementia Due to Mixed Alzheimer and Subcortical Vascular Pathology

The purpose of this study is to determine the clinical, cognitive, motor, brain imaging, genetic and biochemical biomarker characteristics of Alzheimer disease (AD), subcortical vascular disease (SVaD) and mixed dementia (AD + sVaD).

Status
Closed for Recruitment
Principal Investigator
Ging-Yuek Robin Hsiung
Body Locations and Systems
Alzheimer's Disease
Dementia
Area
Vancouver
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