The purpose of this study is to contribute to improving our understanding of functioning in psychosis. Memory is an important predictor of how well individuals affected by schizophrenia and related psychoses are able function in their social and occupational lives. However, the exact structures and functions in the brain responsible for this relationship are currently unknown.
The purpose of this study is to test whether a specific combination of biomarkers discovered during previous studies can help predict how someone experiencing a major depressive episode will respond to treatment. The study will also explore other possible biomarkers that may predict treatment response, which may help in the future development of tests that can guide treatment choice more effectively and more quickly.
The purpose of this study is to investigate if and how retinal blood vessels change after a spinal cord injury (SCI) and the associations of these changes with cardiovascular diseases. Using images of retinal blood vessels, we will develop a deep learning-based screening tool for autonomic dysreflexia, a cardiovascular complication unique to SCI.
The purpose of this study is to look at the link between regions of brain activity and impulsivity and to look at a non-invasive intervention called repetitive transcranial magnetic stimulation (rTMS) to help reduce the risk of impulsive behaviours.
The purpose of the study is to find the best technique and tools for gaining access to left and right heart arteries using x-rays that show blood flow, in patients who are having a specific Medtronic heart valve inserted.
The purpose of this study is to determine if there are sex differences in seatbelt fit by quantifying male and female volunteers’ seatbelt fits relative to external body geometry and skeletal posture using an upright MRI.
The purpose of the study is to compare differences in blood flow and valve pressures by two different methods in patients who are having transcatheter aortic valve replacement.
The purpose of this study is to employ standardized imaging protocols in women and men with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each participant. Participants will be followed for recurrent clinical events, every six months, for a maximum of 10 years.
This is an observational study designed to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health.
The CCNA COMPASS-ND study aims to investigate the bases, commonalities, and distinguishing characteristics of Alzheimer disease and related neurodegenerative disorders.
The purpose of this study is to compare abdominal weight gain and fat distribution to changes in brain morphology in people taking antipsychotic medications.
This trial will compare a novel form of rTMS, intermittent Theta Burst Stimulation to the standard conventional high frequency left sided stimulation protocol. The Left dorsolateral prefrontal cortex will be the site of stimulation in both treatment conditions. The site of stimulation will be targeted using MRI co-registration.
The purpose of this study is to investigate changes in the brain in people affected by Parkinson’s disease using PET and fMRI imaging.
MS is a disabling neurological disease with a highly variable clinical course including acute disability (relapses when symptoms appear or worsen) and disease progression (steady accumulation of disability in the absence of relapses). There is currently no approved treatment for progressive MS. A principal pathology of MS is the destruction of myelin, which surrounds nerves to speed up signal conduction. We have developed a magnetic resonance imaging technique that provides quantitative measurements of myelin.
Parkinson's disease results from the loss of dopamine producing brain cells; however, the mechanism that start and continue this loss are still largerly unknkown. Recent research has suggested a protein called tau may contribute to the development and progression of Parksinon's disease. Using Positron Emission Tomography (PET), a brain imaging technique, we hope to determine if and how much tau is present in healthy control subjects. This control data will then be used for comparison for data collected in patients with Parkinson's and related diseases.
The purpose of this study is to determine the clinical, cognitive, motor, brain imaging, genetic and biochemical biomarker characteristics of Alzheimer disease (AD), subcortical vascular disease (SVaD) and mixed dementia (AD + sVaD).