Healthy Volunteers

The purpose of this study is to explore physicians' perceptions of artificial intelligence (AI) in health care, focusing on how views differ across career stages and specialties. It will examine the impact of generational differences and clinical experience on AI adoption. Additionally, the research will investigate how physicians anticipate their roles evolving as AI automates aspects of medical practice. By analyzing these dimensions, the study aims to provide a nuanced understanding of the medical community’s readiness for AI integration and its implications for clinical workflow.

The purpose of this study is to test a new wearable device developed by the study team to track muscle health and performance during exercise and recovery. This tool will support elite Canadian athletes and their teams in improving training. During cycling and running workouts, sensors will collect data like heart rate, muscle activity and breathing. Using artificial intelligence (AI), researchers will analyze this data to find patterns and predict when muscles start to tire. These insights can help optimize athletic performance and recovery plans.

The purpose of this study is to examine the feasibility of a wireless technology named near-infrared spectroscopy (NIRS) in monitoring leg muscle blood flow and oxygenation and tissue pressure during a protocol of running. The research team will also investigate the ability of non-invasive NIRS in the diagnosis of CECS-induced leg muscle oxygen insufficiency. 

The purpose of this study is to improve how we use magnetic resonance imaging (MRI) to assess new treatments for multiple sclerosis (MS) in the future, and to advance personalized care. Advanced MRI research involves gathering different sequences or images not typically collected on a routine clinical MRI. These images will allow the research team to specifically look at myelin in fine detail along with other measures of brain structure and overall brain health.

The purpose of this study is to collect brain scans, blood samples, memory test scores and cerebrospinal fluid from people with Alzheimer's disease (AD), mild cognitive impairment or no memory impairment. The information collected in the study may help characterize the early stages of AD, and shape the criteria for earlier diagnosis and treatment of AD. It will also be used to discover, standardize and validate measures and biomarkers that are used in AD research. The ADNI4 study is a continuation of the ADNI3 study and will also open to enroll new participants.

The purpose of this study is to contribute to improving our understanding of functioning in psychosis. Memory is an important predictor of how well individuals affected by schizophrenia and related psychoses are able function in their social and occupational lives. However, the exact structures and functions in the brain responsible for this relationship are currently unknown.

The purpose of this study is to collect biospecimens (fecal, urine, blood) and clinical data to serve as a resource for future research on Parkinson’s disease and other movement disorders. The careful collection, storage and retrieval of biospecimens and medical information for research projects are critical for improving understanding of healthy development and disease mechanisms and the subsequent development of effective treatments. Biospecimens from this biobank will be made available for ethically-approved studies.

The purpose of this study is to compare brown adipose tissue (BAT) activity in women/people diagnosed with endometriosis to similar healthy controls. BAT activity is measured twice in a random order during the early part of the menstrual cycle (follicular phase) and following egg release/ovulation (luteal phase). The study team will investigate whether BAT activity in women with endometriosis differs from healthy control women who are of similar age and body mass index.

The purpose of this study is to determine if a 26-week health coaching program can increase time spent in moderate to vigorous physical activity and improve mobility compared with a 26-week group health education program in older adults with limited mobility.

The purpose of this study is to investigate the safety and tolerability of Montbretin A, a new natural health product made from garden flower, in treating healthy individuals or individuals with type 2 diabetes by reducing hyperglycemia episodes.

The purpose of this study is to test whether a specific combination of biomarkers discovered during previous studies can help predict how someone experiencing a major depressive episode will respond to treatment. The study will also explore other possible biomarkers that may predict treatment response, which may help in the future development of tests that can guide treatment choice more effectively and more quickly.

The purpose of this study is to investigate prosthetists' and occupational therapists' perceptions of 3D printing and explore their perspectives on the potential application of this technology in clinical settings through interviews.

The purpose of this study is to understand the link between schizophrenia and heat. People with schizophrenia have died at disproportionately high rates in recent heat events. While there is some physiological and biomedical understanding of thermoregulation in people with schizophrenia, understandings of their social vulnerability is lacking. Through interviews with people with schizophrenia, as well as their caregivers and loved ones, the study team aims to get a fuller understanding of their experiences in extreme heat events.

The purpose of this study is to investigate the effects of cannabis in people using recreational cannabis. This research will examine the cognitive and emotional effects of cannabis oil.

The purpose of the study is to investigate the effects of different types of exercise training on cognitive function. Investigators aim to assess the individual effects of aerobic and resistance training, as well as the interaction effect of combining the two types of exercise training, on cognitive function in older adults with mild cognitive impairment.

The purpose of this study is to test visual abilities and eye movements in patients with Parkinson's disease and healthy control participants and to link dysfunctions to cognitive abilities and disease severity.

Recruitment Poster

The purpose of this study is to explore whether heart rate variability (HRV) normalization may serve as a surrogate marker of the changes in brain function caused by repetitive transcranial magnetic stimulation (rTMS) that are associated with symptomatic improvement in depression.

The purpose of this study is to investigate the impact of genetic and non-genetic risk factors for Alzheimer’s disease (AD), evaluate differential
effects of sex on AD risk, and predict diagnosis of AD using dementia risk scores derived from genetic and nongenetic risk factors.

The purpose of this study is to determine if there are sex differences in seatbelt fit by quantifying male and female volunteers’ seatbelt fits relative to external body geometry and skeletal posture using an upright MRI. 

The purpose of this study is to is to examine the effects of 12 weeks of high-intensity interval training on the cognitive health of perimenopausal women.