Body Systems

Arteries13 Results found

Studies recruiting participants:

The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial…

The objective of this clinical trial is to compare the efficacy and safety of an initial triple oral treatment regimen (macitentan, tadalafil, selexipag) versus an initial dual oral treatment regimen (macitentan, tadalafil, placebo) in newly diagnosed, treatment-naïve patients with pulmonary arte

Recruiting
Principal Investigator 
John Swiston
Body Locations and Systems 
Arteries, Pulmonary Hypertension
Area 
Vancouver
Age 
18-75

Telmisartan vs. Perindopril in Hypertensive Mild-Moderate Alzheimer's Disease Patients (SARTAN-AD)

The purpose of this project is to conduct a proof of concept study in patients with probable Alzheimer's Disease who have mild to moderate hypertension, in order to determine if there is less global brain atrophy over one year, as measured by ventricular enlargement as a primary outcome measure,

Recruiting
Principal Investigator 
Ging-Yuek Robin Hsiung
Body Locations and Systems 
Alzheimer's Disease, High Blood Pressure
Area 
Vancouver
Age 
55 and above

Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST

This study assesses the safety and efficacy of bardoxolone methyl relative to placebo in patients with connective tissue disease-associated pulmonary arterial hypertension to determine the recommended dose range and evaluate the change from baseline in 6-minute walk distance (6MWD) following 24 w

Recruiting
Principal Investigator 
John Swiston
Body Locations and Systems 
High Blood Pressure
Area 
Vancouver
Age 
18-75

Insulin Therapy and Falls Due to Orthostatic Hypotension

In the proposed study, the investigators examine in older adults with Type 2 diabetes the impact of beginning insulin therapy on the orthostatic drop in blood pressure as well as the response of arterial blood pressure and Doppler measures of cerebral blood flow during upright tilt.

Recruiting
Principal Investigator 
Kenneth Madden
Body Locations and Systems 
Low Blood Pressure
Area 
Vancouver
Age 
65 and above

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery…

The purpose of study is to test whether rivaroxaban added to standard of care treatment, when compared to placebo, has the potential to reduce the incidence of the clinical events related to the clots and complications of the heart and brain (CV death, MI, or stroke) or the legs (acute limb ische

Recruiting
Principal Investigator 
Jerry C.L. Chen
Body Locations and Systems 
Peripheral Arterial Disease
Area 
Vancouver
Age 
50 and above

Closed for recruitment:

Zenith Alpha™ Abdominal Endovascular Graft

The purpose of this study is to evaluate the clinical performance of the Zenith Alpha™ Abdominal Endovascular Graft for the treatment of abdominal aortic or aorto-iliac aneurysm.

Closed for Recruitment
Principal Investigator 
Jerry C.L. Chen
Body Locations and Systems 
Aneurysms
Area 
Vancouver
Age 
18 and above

Assessment of Blood-Borne Autologous Angiogenic Cell Precursors Therapy in Patients With Critical Limb Ischemia

A randomized, double-blind placebo controlled study to determine the safety and efficacy of Angiogenic Cell Precursors (ACPs) in relieving symptoms of Critical Limb Ischemia in patients treated with standard of care and with no surgical revascularization option.

Closed for Recruitment
Principal Investigator 
York Hsiang
Body Locations and Systems 
Peripheral Arterial Disease
Area 
Vancouver
Age 
18 and above