A Trial to Evaluate the Safety and Efficacy of Elamipretide in Subjects With Primary Mitochondrial Myopathy Followed by an Open-Label…The purpose of this study is to evaluate the safety and efficacy of daily subcutaneous injections of elamipretide in subjects with primary mitochondrial myopathy. Recruiting Principal Investigator Anna LehmanBody Locations and Systems Muscles, Neuromuscular DisordersArea VancouverAge 16-80
Metformin in Patients Initiating ADT as Prevention and Intervention of Metabolic Syndrome (PRIME)The purpose of this study is to determine if there are differences between patients who receive metformin or placebo with respect to the proportion of patients who meet the diagnostic criteria for metabolic syndrome after 18 months of study treatment. Recruiting Principal Investigator Alan I. SoBody Locations and Systems Prostate CancerArea VancouverAge 18 and above
A Study to Evaluate the Efficacy and Safety of Daratumumab in Combination With Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) Compared to…The purpose of this study is to evaluate the efficacy and safety of daratumumab plus cyclophosphamide, bortezomib and dexamethasone (CyBorD) compared with CyBorD alone in treatment of newly diagnosed amyloid light chain (AL) amyloidosis participants. Recruiting Principal Investigator Kevin SongArea VancouverAge 18 and above
HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)The purpose of this study is to evaluate the efficacy and safety of vutrisiran (ALN-TTRSC02) in patients with hereditary transthyretin amyloidosis (hATTR amyloidosis). Recruiting Principal Investigator Michelle M. MezeiArea VancouverAge 18-85
A Pilot Study Comparing the Use of Low-target Versus Conventional Target Advagraf (Astellas)While the incidence of acute rejection and early graft loss have improved dramatically with the advent of newer immunosuppressant medications, improvements in long-term patient and allograft survival after kidney transplantation have not been achieved.Recruiting Principal Investigator Jagbir GillBody Locations and Systems Kidney TransplantationArea VancouverAge 19 and above
Insulin Therapy and Falls Due to Orthostatic HypotensionIn the proposed study, the investigators examine in older adults with Type 2 diabetes the impact of beginning insulin therapy on the orthostatic drop in blood pressure as well as the response of arterial blood pressure and Doppler measures of cerebral blood flow during upright tilt.Recruiting Principal Investigator Kenneth MaddenBody Locations and Systems Low Blood PressureArea VancouverAge 65 and above
Macular Involvement in Diabetic Retinopathy Evaluated With Swept-Source OCTIn this study capillary changes of patients with different severity levels of diabetic retinopathy will be investigated with non-invasive imaging technology to better understand the process of disease progression. Recruiting Principal Investigator Eduardo NavajasBody Locations and Systems Diabetic Eye ProblemsArea VancouverAge 18 and above
Hypoglycemia (Low Blood Sugar) and the HeartThe risk of hypoglycemia (low blood sugar) associated with the treatment of diabetes increases with age. Hypoglycemia is a common reason for admission to hospital for older patients with diabetes.Recruiting Principal Investigator Graydon S. MeneillyBody Locations and Systems Diabetes - Type 2Area VancouverAge 70 and above
Peripheral Diabetic Retinopathy (DR) Lesions on Ultrawide-field Fundus Images and Risk of DR Worsening Over Time To determine the association between peripheral diabetic retinopathy lesions and the likelihood of diabetic retinopathy worsening or improving over time. Closed for Recruitment Principal Investigator David MaberleyBody Locations and Systems Diabetic Eye Problems, Diabetes - Type 1, Diabetes - Type 2Area VancouverAge 18 and above
A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular…This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study in overweight and obese subjects with CV disease and/or multiple CV risk factors. Closed for Recruitment Principal Investigator Graham WongBody Locations and Systems Diabetes - Type 2, Coronary Artery DiseaseArea VancouverAge 40 and above
