The Longitudinal Course of Intracortical Myelination and Cognitive Function in Bipolar DisorderThe purpose of this study is to see whether the loss of a specific substance (called myelin) in the outer part of the brain accounts for poor cognitive function in participants with bipolar disorder as compared to healthy participants. Recruiting Principal Investigator Lakshmi N. YathamBody Locations and Systems Bipolar DisorderArea VancouverAge 16-45
Efficacy of Convulsive Therapies for Bipolar Depression (CORRECT-BD)The purpose of this study is to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for Bipolar Disorder (BD). Recruiting Principal Investigator Fidel Vila-RodriguezBody Locations and Systems Bipolar Disorder, DepressionArea VancouverAge 18 and above
Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar DisorderPatients with bipolar I disorder (BD) experience depression 3 times more frequently than mania, and antidepressants are prescribed as adjuncts to mood stabilizers in up to 70% of patients.Recruiting Principal Investigator Lakshmi N. YathamBody Locations and Systems Bipolar DisorderArea VancouverAge 18-70
Comparison of Aripiprazole Versus Risperidone on Brain Morphology Using MRI (CARB)Significant changes in brain morphology are observed in people with first-episode psychosis. Studies have shown that total brain volume and particular brain structures are decreased in people with psychosis disorders.Recruiting Principal Investigator Alasdair BarrBody Locations and Systems Bipolar DisorderArea VancouverAge 12 and above
Bipolar Depression and the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS)The purpose of this study is to assess the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive (does not enter the body) technique in improving depressive symptoms.Recruiting Principal Investigator Lakshmi N. YathamBody Locations and Systems Bipolar Disorder, DepressionArea VancouverAge 18-70
Study of the Efficacy of Lurasidone in Cognitive Functioning in Bipolar Patients (ELICE_BD)This is a randomized, double-blind, placebo-controlled, multicentre, parallel-group study to assess the cognitive effects of lurasidone in bipolar I and II patients (manic depression) who are in remission from an episode.Recruiting Principal Investigator Lakshmi N. YathamBody Locations and Systems Bipolar Disorder, Men's and Women's HealthArea VancouverAge 19-65
