Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar DisorderPatients with bipolar I disorder (BD) experience depression 3 times more frequently than mania, and antidepressants are prescribed as adjuncts to mood stabilizers in up to 70% of patients. Principal Investigator Lakshmi N. YathamBody Locations and Systems Bipolar DisorderArea VancouverAge 18-70
Comparison of Aripiprazole Versus Risperidone on Brain Morphology Using MRI (CARB)Significant changes in brain morphology are observed in people with first-episode psychosis. Studies have shown that total brain volume and particular brain structures are decreased in people with psychosis disorders. Principal Investigator Alasdair BarrBody Locations and Systems Bipolar DisorderArea VancouverAge 12 and above
Efficacy of rTMS in Bipolar I Depression (rTMS-BD)Bipolar-I Disorder is a common condition that is characterized by periods of mood elevation however periods of chronic and recurring depressive episodes are more common and can be severely disabling. Principal Investigator Lakshmi N. YathamBody Locations and Systems Bipolar Disorder, DepressionArea VancouverAge 18-70
Study of the Efficacy of Lurasidone in Cognitive Functioning in Bipolar Patients (ELICE_BD)This is a randomized, double-blind, placebo-controlled, multicentre, parallel-group study to assess the cognitive effects of lurasidone in bipolar I and II patients (manic depression) who are in remission from an episode. Principal Investigator Lakshmi N. YathamBody Locations and Systems Bipolar Disorder, Men's and Women's HealthArea VancouverAge 19-65
