Asthma Self-management Via Application of Telehealth (asthma)The disease being studied is asthma. Principal Investigator Mark FitzGeraldBody Locations and Systems AsthmaArea VancouverAge 19-85
Corticosteroid Plus LABA (BORA)…The purpose of this study is to characterize the safety profile of benralizumab administration in asthma patients who have completed one of the three predecessor studies: D3250C00017, D3250C00018 or D3250C00020. Principal Investigator Mark FitzGeraldBody Locations and Systems AsthmaArea VancouverAge 12-75
A Clinical Study to Evaluate Symbicort Turbuhaler Used 'as Needed' in Adults and Adolescents With Asthma (SYGMA1)The purpose of this study is to test if Symbicort® (budesonide/formoterol) Turbuhaler® is effective in treating asthma when used 'as needed' in patients with milder asthma. Principal Investigator Mark FitzGeraldBody Locations and Systems AsthmaArea VancouverAge 12-130
Longitudinal Cohort Study in Participants With Severe Asthma to Assess BiomarkersProspective, single-arm, longitudinal, international, multicentre study in a real-world cohort of adult severe asthma participants being conducted to assess the relationships between asthma biomarkers and asthma-related health-outcomes for a period of 52 weeks. Principal Investigator Mark FitzGeraldBody Locations and Systems AsthmaArea VancouverAge 18 and above
Salbutamol, Air Pollution and Breathing MechanicsWhen exposed to air pollution, the asthma symptoms are aggravated and lung function is impaired. Due to high breathing rates and volumes, athletes are at particular risk of lung health impairment due to the high breathing rates and volumes. Body Locations and Systems Asthma
Evaluation of Dupilumab in Patients With Persistent AsthmaPrimary Objective: To evaluate the efficacy of dupilumab (SAR231893 [REGN668]) in patients with persistent asthma. Secondary Objectives: Principal Investigator Mark FitzGeraldBody Locations and Systems AsthmaArea VancouverAge 12 and above
Efficacy and Safety of BI 655066/ABBV-066 (Risankizumab) in Patients With Severe Persistent AsthmaThe objectives of this trial are primarily to evaluate the efficacy and safety of BI 655066 as compared to placebo over a 24-week treatment period in severe asthma patients. The primary endpoint is time to first asthma worsening during the planned 24 week treatment period for active vs. Principal Investigator Mark FitzGeraldBody Locations and Systems AsthmaArea VancouverAge 18-75
Study to Evaluate Efficacy & Safety of Tralokinumab in Subjects With Asthma Inadequately Controlled on Corticosteroids (MESOS)A Multicentre, Randomized, Double-blind, Parallel Group, Placebo Controlled, 12-Week, Phase 2 Study to Evaluate the Effect of Tralokinumab on Airway Inflammation in Adults with Asthma Inadequately Controlled on Inhaled Corticosteroid. Principal Investigator Mark FitzGeraldBody Locations and Systems AsthmaArea VancouverAge 18-75
Omalizumab to Mepolizumab Switch Study in Severe Eosinophilic Asthma PatientsMepolizumab is an anti-interleukin-5 ( IL-5) monoclonal antibody that neutralizes IL-5 and reduces eosinophil counts in both sputum and blood. Omalizumab an anti-immunoglobulin E (IgE) monoclonal antibody (mAb) is effective in the treatment of moderate to severe allergic asthma. Principal Investigator Mark FitzGeraldBody Locations and Systems AsthmaArea VancouverAge 12 and above
Study of Efficacy and Safety of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.This study aims to determine the efficacy and safety of QAW039 (Dose 1 and Dose 2), compared with placebo, when added to GINA steps 4 and 5 standard-of- care (SoC) asthma therapy (GINA 2015) in each of the groups (patients with severe asthma and high eosinophil counts and all patients with severe Principal Investigator Mark FitzGeraldBody Locations and Systems AsthmaArea VancouverAge 12 and above
Long-Term Safety Evaluation of Dupilumab in Patients With Asthma (LIBERTY ASTHMA TRAVERSE)Primary Objective: Evaluate the long-term safety and tolerability of dupilumab in patients with asthma who participated in a previous dupilumab asthma study. Secondary Objectives: Principal Investigator Mark FitzGeraldBody Locations and Systems AsthmaArea VancouverAge 12 and above
Study to Evaluate the Effect of Benralizumab on Allergen-Induced Inflammation in Mild, Atopic Asthmatics (ARIA)This is a randomized, double-blind, parallel group, placebo-controlled study designed to evaluate the effect of a fixed 30 mg dose of benralizumab administered subcutaneously every 4 weeks on allergen-induced inflammation in subjects with mild atopic asthma challenged with an inhaled allergen. Principal Investigator Mark FitzGeraldBody Locations and Systems AsthmaArea VancouverAge 18-65
