Significant changes in brain morphology are observed in people with first-episode psychosis. Studies have shown that total brain volume and particular brain structures are decreased in people with psychosis disorders.

This is a randomized, double-blind, placebo-controlled, multicentre, parallel-group study to assess the cognitive effects of lurasidone in bipolar I and II patients (manic depression) who are in remission from an episode.

This trial will compare a novel form of rTMS, intermittent Theta Burst Stimulation to the standard conventional high frequency left sided stimulation protocol. The Left dorsolateral prefrontal cortex will be the site of stimulation in both treatment conditions.

To look at the differences in "social cognition"-the ability to look at the interpret the social world and put yourself in someone else's shoes-between people with depression,people with frontotemporal dementia, and healthy controls.

The purpose of this trial is to identify biomarkers of response to repetitive transcranial magnetic stimulation (rTMS) in individuals with first episode or treatment resistant depression.

The perception of music requires coordinated neural activities in distributed multi-functional centers across both hemispheres. The association between musical abilities and other general cognitive functions have been studied in several populations with inconsistent results.

To determine the effects of aerobic exercise on hippocampal volumes and severity of psychotic symptoms in a population of psychosis patients compared to healthy age/gender matched volunteers.

This study investigates the use of eye tracking technology as a diagnostic tool for mild traumatic brain injury (mTBI) and concussion. We are looking at the effect of additional working memory (short-term memory) load on the smoothness of eye movements in both concussed and healthy populations.

The goal of the current study is to determine the prevalence, rate, and types of pregnancy complications and early life events that may be associated with the emergence of psychosis and related metabolic disorder in patients with schizophrenia spectrum disorders.

This trial evaluates two standard of care treatments for opioid addiction: methadone and buprenorphine/naloxone.  The goal of this study is to determine the efficacy and safety of buprenorphine/naloxone as an alternative treatment for prescription opioid disorder.