Significant changes in brain morphology are observed in people with first-episode psychosis. Studies have shown that total brain volume and particular brain structures are decreased in people with psychosis disorders.

Bipolar-I Disorder is a common condition that is characterized by periods of mood elevation however periods of chronic and recurring depressive episodes are more common and can be severely disabling.

This is a randomized, double-blind, placebo-controlled, multicentre, parallel-group study to assess the cognitive effects of lurasidone in bipolar I and II patients (manic depression) who are in remission from an episode.

The purpose of this study is to determine the clinical, cognitive, motor, brain imaging, genetic and biochemical biomarker characteristics of Alzheimer disease (AD), subcortical vascular disease (SVaD) and mixed dementia (AD + sVaD).

To look at the differences in "social cognition"-the ability to look at the interpret the social world and put yourself in someone else's shoes-between people with depression,people with frontotemporal dementia, and healthy controls.

The CCNA COMPASS-ND study aims to investigate the bases, commonalitites, and distinguishing characteristics of Alzheimer disease and related neurodegenerative disorders. 

recruitment poster

Repetitive transcranial magnetic (rTMS) is a safe, noninvasive treatment that involves placing a magnetic coil on a person’s head over an area of the brain called the dorsolateral prefrontal cortex (DLPFC).

This trial will compare a novel form of rTMS, intermittent Theta Burst Stimulation to the standard conventional high frequency left sided stimulation protocol. The Left dorsolateral prefrontal cortex will be the site of stimulation in both treatment conditions.

Parkinson's disease (PD) is a progressive neurological disease that has effects on both movement and mental health. One of the most common mental health complications of PD is depression. Up to 30% of Parkinson's patients will experience depression at some point.

tDCS (transcranial Direct Current Stimulation) is a brain stimulation technique that involves passing a very low current through the scalp to change the excitability of underlying brain regions. Moreover, yoga and meditation have recently gained popularity for their proposed health benefits.

The purpose of this study is to test whether an investigational drug called solanezumab can slow the progression of memory problems associated with brain amyloid (protein that forms plaques in the brains of people with Alzheimer Disease [AD]).

Losing the ability to walk can lead to fewer opportunities to socialize with friends and family, and participate in the community. When this happens, powered wheelchairs can provide access to homes and communities, contributing to health and well-being.

This is a prospective, multicenter, randomized, double-blinded clinical trial exploring the efficacy and safety of rivaroxaban as compared to acetylsalicylic acid in reducing stroke, transient ischemic attack (TIA) and neurocognitive decline, in subjects with non-valvular AF and with low risk of

The primary objective of the study is to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo in participants with early AD.

We are recruiting people 65 and older to learn about the brain function differences between those who take falls, and those who do not. We will compare degree of cognitive decline over 12 months between fallers and non-fallers through brain scans (fMRI).

The purpose of this study is to determine whether various exercise programs are able to combat cognitive decline.  These include an aerobic training exercise program, a resistance training exercise program, a combination exercise program of aerobic and resistance training, and a balance and tone