Patients with bipolar I disorder (BD) experience depression 3 times more frequently than mania, and antidepressants are prescribed as adjuncts to mood stabilizers in up to 70% of patients.

This is a randomized, double-blind, placebo-controlled, multicentre, parallel-group study to assess the cognitive effects of lurasidone in bipolar I and II patients (manic depression) who are in remission from an episode.

The investigators will conduct a proof-of-concept randomized controlled trial study to provide preliminary evidence of efficacy of a resistance exercise training program for maintaining white matter integrity and improving cognitive function in older adults with vascular cognitive impairment, com

To determine the effects of aerobic exercise on hippocampal volumes and severity of psychotic symptoms in a population of psychosis patients compared to healthy age/gender matched volunteers.

The goal of the current study is to determine the prevalence, rate, and types of pregnancy complications and early life events that may be associated with the emergence of psychosis and related metabolic disorder in patients with schizophrenia spectrum disorders.

tDCS (transcranial Direct Current Stimulation) is a brain stimulation technique that involves passing a very low current through the scalp to change the excitability of underlying brain regions. Moreover, yoga and meditation have recently gained popularity for their proposed health benefits.

The purpose of this study is to assess the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive (does not enter the body) technique in improving depressive symptoms.

The purpose of this study is to compare the effectiveness of three different treatment options for those dealing with treatment-resistant depression.  The three different treatment options are: (1) adding aripiprazole to their current treatment, (2) adding repetitive transcranial magnetic stimula

The purpose of this study is to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for Bipolar Disorder (BD).

Losing the ability to walk can lead to fewer opportunities to socialize with friends and family, and participate in the community. When this happens, powered wheelchairs can provide access to homes and communities, contributing to health and well-being.

This is a prospective, multicenter, randomized, double-blinded clinical trial exploring the efficacy and safety of rivaroxaban as compared to acetylsalicylic acid in reducing stroke, transient ischemic attack (TIA) and neurocognitive decline, in subjects with non-valvular AF and with low risk of

This is a prospective, multicenter, randomized, double-blinded clinical trial exploring the efficacy and safety of rivaroxaban as compared to acetylsalicylic acid in reducing stroke, transient ischemic attack (TIA) and neurocognitive decline, in subjects with non-valvular AF and with low risk of

Significant changes in brain morphology are observed in people with first-episode psychosis. Studies have shown that total brain volume and particular brain structures are decreased in people with psychosis disorders.

The purpose of this study is to determine whether various exercise programs are able to combat cognitive decline.  These include an aerobic training exercise program, a resistance training exercise program, a combination exercise program of aerobic and resistance training, and a balance and tone

The objectives of this 15-day study are:

Current Canadian Clinical Practice guidelines emphasize the need for effective psychosocial adjuncts to pharmacotherapy for schizophrenia (Canadian Psychiatric Association 2005).