Comparing three different treatment options for those with treatment-resistant depression (ASCERTAIN-TRD)The purpose of this study is to compare the effectiveness of three different treatment options for those dealing with treatment-resistant depression. The three different treatment options are: (1) adding aripiprazole to their current treatment, (2) adding repetitive transcranial magnetic stimulaRecruiting Principal Investigator Fidel Vila-RodriguezBody Locations and Systems DepressionArea VancouverAge 18-80
Investigating Predictors of Treatment Response in Treatment-Resistant Depression (TRD) With Interleaved TMS/fMRIThe purpose of this trial is to identify biomarkers of response to repetitive transcranial magnetic stimulation (rTMS) in individuals with first episode or treatment resistant depression. Recruiting Principal Investigator Fidel Vila-RodriguezBody Locations and Systems DepressionArea VancouverAge 18-80
Efficacy of Convulsive Therapies for Bipolar Depression (CORRECT-BD)The purpose of this study is to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for Bipolar Disorder (BD). Recruiting Principal Investigator Fidel Vila-RodriguezBody Locations and Systems Bipolar Disorder, DepressionArea VancouverAge 18 and above
Neuropsychology and treatment response in depressionThis study aims to assess whether initial neuropsychological functioning and early changes in emotional processing in depressed adults correlates with symptom response to medications.Recruiting Principal Investigator Ivan TorresBody Locations and Systems DepressionArea VancouverAge 18-65
Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation StudyThe purpose of this study is to learn about biomarkers (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression. Recruiting Principal Investigator Raymond LamBody Locations and Systems DepressionArea VancouverAge 18-60
Study of the Efficacy of Lurasidone in Cognitive Functioning in Bipolar Patients (ELICE_BD)This is a randomized, double-blind, placebo-controlled, multicentre, parallel-group study to assess the cognitive effects of lurasidone in bipolar I and II patients (manic depression) who are in remission from an episode.Recruiting Principal Investigator Lakshmi N. YathamBody Locations and Systems Bipolar Disorder, Men's and Women's HealthArea VancouverAge 19-65
The effect of secondary attentional tasks on smooth pursuit eye movements and reaction time in mild traumatic brain injuryThis study investigates the use of eye tracking technology as a diagnostic tool for mild traumatic brain injury (mTBI) and concussion. We are looking at the effect of additional working memory (short-term memory) load on the smoothness of eye movements in both concussed and healthy populations.Recruiting Principal Investigator William PanenkaBody Locations and Systems Traumatic Brain Injury, Men's and Women's HealthArea VancouverAge 18-50
Wellness Monitoring for Major Depressive DisorderThe Wellness Monitoring for Major Depressive Disorder (MDD) study is a prospective, longitudinal, observational study aimed at identifying biomarkers of relapse in MDD.Recruiting Principal Investigator Raymond LamBody Locations and Systems DepressionArea VancouverAge 18-60
Brain Health and Exercise in Schizophrenia (PEHP)To determine the effects of aerobic exercise on hippocampal volumes and severity of psychotic symptoms in a population of psychosis patients compared to healthy age/gender matched volunteers.Recruiting Principal Investigator Donna Jane M LangBody Locations and Systems BrainArea VancouverAge 16-45
Birth, childhood health and psychosis outcomesThe goal of the current study is to determine the prevalence, rate, and types of pregnancy complications and early life events that may be associated with the emergence of psychosis and related metabolic disorder in patients with schizophrenia spectrum disorders.Recruiting Principal Investigator Donna Jane M LangBody Locations and Systems Men's and Women's HealthArea VancouverAge 16-45
Study of the Effect of Dosing on Clozapine Levels (PK-CLZ)The objectives of this 15-day study are:Recruiting Principal Investigator Ric ProcyshynBody Locations and Systems BrainArea VancouverAge 19-65
Exploring the Effects of Yoga, Meditation, and tDCS Brain StimulationtDCS (transcranial Direct Current Stimulation) is a brain stimulation technique that involves passing a very low current through the scalp to change the excitability of underlying brain regions. Moreover, yoga and meditation have recently gained popularity for their proposed health benefits.Recruiting Principal Investigator Fidel Vila-RodriguezBody Locations and Systems Men's and Women's HealthArea VancouverAge 18-35
The Music Study in Refractory Psychosis (MARS)The perception of music requires coordinated neural activities in distributed multi-functional centers across both hemispheres. The association between musical abilities and other general cognitive functions have been studied in several populations with inconsistent results.Recruiting Principal Investigator Alasdair BarrBody Locations and Systems BrainArea VancouverAge 18 and above
COVID-19 NeuroOutcomes (CONOS)This study is exploring certain aspects of the blood and brain to determine how a person may recover from COVID-19. In addition, this study will examine how the different aspects of COVID-19 may affect how a person thinks or feels. Recruiting Principal Investigator William PanenkaBody Locations and Systems BrainArea VancouverAge 14-90
Contrasting Group Therapy Methods for Psychosis (MCT)Current Canadian Clinical Practice guidelines emphasize the need for effective psychosocial adjuncts to pharmacotherapy for schizophrenia (Canadian Psychiatric Association 2005).Recruiting Principal Investigator Todd WoodwardBody Locations and Systems BrainArea VancouverAge 19-60
Longitudinal Study of the Clinical Epidemiology of Parkinson's Disease and Parkinson Plus SyndromesThe purpose of this study is to establish a local registry comprised of patients with Parkinson's Disease and Parkinson Plus Syndromes to mainstream research efforts and find more efficient ways to treat Parkinson's Disease. Recruiting Principal Investigator Martin McKeownBody Locations and Systems Parkinson's DiseaseArea Vancouver
Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT)The purpose of this study is to assess the effects of the COVID-19 outbreak and related quarantine measures on the physical and mental well-being of health care workers, as well as the general population. Recruiting Principal Investigator Lakshmi N. YathamArea VancouverAge 6 and above
A virtual reality intervention to improve workplace functioning in depression: Health professional end user interviewsThe purpose of this study is gather qualitative data from clinicians and care providers to assess the feasibility and efficacy of implementing a novel cognitive remediation program for treating treating cognitive deficits related to depression through the usage of immersive virtual reality. Recruiting Principal Investigator Trisha ChakrabartyArea VancouverAge 18 and above
Co-Investigation of Robotic-Assisted Virtual Care for Older People with Dementia - Phase 1The purpose of this study is to determine ways to meet the social needs related to loneliness and isolation in seniors with dementia while examing barriers and successes surrounding the use of a robot-assisted, virtual care solution within care settings. Recruiting Principal Investigator Lillian HungBody Locations and Systems DementiaArea VancouverAge 18 and above
A Pragmatic Randomized Control Trial Comparing Models of Care in the Management of Prescription Opioid Misuse (OPTIMA)This trial evaluates two standard of care treatments for opioid addiction: methadone and buprenorphine/naloxone. The goal of this study is to determine the efficacy and safety of buprenorphine/naloxone as an alternative treatment for prescription opioid disorder. Recruiting Principal Investigator Keith AhamadArea VancouverAge 18-64
Treating Anxiety in Parkinson's Disease With a Multi-Strain Probiotic (TAP)The purpose of this study is to evaluate the use of an oral multi-strain probiotic in the treatment of anxiety in individuals with Parkinson's Disease. Recruiting Principal Investigator Silke CresswellBody Locations and Systems Parkinson's DiseaseArea VancouverAge 40 - 80
Low-dose vs. Normal-dose Psychostimulants on Executive Functions in Children With ADHDThis double-blind crossover study aims to compare cognitive performance (e.g., working memory, selective attention and cognitive flexibility) of children ages 6-18 years diagnosed with ADHD of the combined type (ADHD-C) or inattentive-type (ADHD-IA) and currently on > 20 mg/day of psychostimulRecruiting Principal Investigator Adele DiamondBody Locations and Systems BrainArea VancouverAge 6-18
Comparison of Aripiprazole Versus Risperidone on Brain Morphology Using MRI (CARB)Significant changes in brain morphology are observed in people with first-episode psychosis. Studies have shown that total brain volume and particular brain structures are decreased in people with psychosis disorders.Recruiting Principal Investigator Alasdair BarrBody Locations and Systems Bipolar DisorderArea VancouverAge 12 and above
Healthy male volunteers in their 50’s needed for research study on depressionThis trial will compare a novel form of rTMS, intermittent Theta Burst Stimulation to the standard conventional high frequency left sided stimulation protocol. The Left dorsolateral prefrontal cortex will be the site of stimulation in both treatment conditions.Recruiting Principal Investigator Fidel Vila-RodriguezBody Locations and Systems DepressionArea VancouverAge 51-60
tDCS in Parkinson's Disease With DepressionParkinson's disease (PD) is a progressive neurological disease that has effects on both movement and mental health. One of the most common mental health complications of PD is depression. Up to 30% of Parkinson's patients will experience depression at some point.Recruiting Principal Investigator A Jon StoesslBody Locations and Systems Parkinson's Disease, DepressionArea VancouverAge 19 and above
Developing a risk assessment tool for discriminating social cognition deficits in dementia from that of depressionTo look at the differences in "social cognition"- the ability to look at the interpret the social world and put yourself in someone else's shoes - between people with depression, people with frontotemporal dementia and healthy controls. Recruiting Principal Investigator Howard FeldmanBody Locations and Systems Dementia, DepressionArea VancouverAge 40-80
Bipolar Depression and the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS)The purpose of this study is to assess the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive (does not enter the body) technique in improving depressive symptoms.Closed for Recruitment Principal Investigator Lakshmi N. YathamBody Locations and Systems Bipolar Disorder, DepressionArea VancouverAge 18-70
Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar DisorderPatients with bipolar I disorder (BD) experience depression 3 times more frequently than mania, and antidepressants are prescribed as adjuncts to mood stabilizers in up to 70% of patients.Closed for Recruitment Principal Investigator Lakshmi N. YathamBody Locations and Systems Bipolar DisorderArea VancouverAge 18-70
rTMS in the Treatment of PTSDRepetitive transcranial magnetic (rTMS) is a safe, noninvasive treatment that involves placing a magnetic coil on a person’s head over an area of the brain called the dorsolateral prefrontal cortex (DLPFC).Closed for Recruitment Principal Investigator Larry OngBody Locations and Systems BrainArea VancouverAge 19-70
Study of the Effects of Pantoprazole on Levels of Prescribed Psychiatric Medications (PK-PPI)The purpose of this 9-day study is to determine if:Closed for Recruitment Principal Investigator Ric ProcyshynBody Locations and Systems BrainArea VancouverAge 19-65
Real Life Assessment of Abilify Maintena (ReLiAM)This is a non-interventional, Canadian, study in patients treated with Abilify Maintena™ for schizophrenia followed for 24 months, with 9 visits recommended.Closed for Recruitment Principal Investigator Soma GanesanBody Locations and Systems BrainArea VancouverAge 18 and above
Canadian Biomarker Integration Network for Depression Study (CAN-BIND-1)This study is a pilot to assess feasibility of the protocol in patients and controls across six participating sites.Closed for Recruitment Principal Investigator Raymond LamBody Locations and Systems DepressionArea VancouverAge 18-60
Canadian rTMS Treatment and Biomarker Network in Depression Trial (CARTBIND)Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for medically refractory major depressive disorder (MDD). rTMS involves direct stimulation of cortical neurons using externally applied, powerful, focused magnetic field pulses.Closed for Recruitment Principal Investigator Fidel Vila-RodriguezBody Locations and Systems DepressionArea VancouverAge 18-59
