Characterization of Dementia Due to Mixed Alzheimer and Subcortical Vascular Pathology The purpose of this study is to determine the clinical, cognitive, motor, brain imaging, genetic and biochemical biomarker characteristics of Alzheimer disease (AD), subcortical vascular disease (SVaD) and mixed dementia (AD + sVaD). Principal Investigator Ging-Yuek Robin HsiungBody Locations and Systems Alzheimer's Disease, DementiaArea Vancouver
Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)…The purpose of this study is to assess the safety, tolerability, biomarker and cognitive efficacy of gantenerumab and solanezumab in subjects who are known to have an Alzheimer's disease-causing mutation by determining if treatment with the study drug improves cognitive outcomes and disease-relat Principal Investigator Ging-Yuek Robin HsiungBody Locations and Systems Alzheimer's Disease, Neurologic Diseases, DementiaArea VancouverAge 18-80
Developing a risk assessment tool for discriminating social cognition deficits in dementia from that of depressionTo look at the differences in "social cognition"-the ability to look at the interpret the social world and put yourself in someone else's shoes-between people with depression,people with frontotemporal dementia, and healthy controls. Principal Investigator Howard FeldmanBody Locations and Systems Dementia, DepressionArea VancouverAge 40-80
Open-Label Study of TRx0237 in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD)The purpose of this study is to provide subjects who have completed participation in a Phase 2 or Phase 3 trial with TRx0237 continued access to therapy and to evaluate the long-term safety of TRx0237. Principal Investigator Ging-Yuek Robin HsiungBody Locations and Systems Alzheimer's Disease, DementiaArea Vancouver
Reshaping the Path of Vascular Cognitive Impairment (VCI)The investigators will conduct a proof-of-concept randomized controlled trial study to provide preliminary evidence of efficacy of a resistance exercise training program for maintaining white matter integrity and improving cognitive function in older adults with vascular cognitive impairment, com Principal Investigator Teresa Y.L. Liu-AmbroseArea VancouverAge 55 and above
